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5 Star Hotels in Houston

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Featured 5 Star Houston Hotels

The Post Oak Hotel at Uptown Houston
5 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from MD Anderson Cancer Center
The price is $653 per night from Nov 28 to Nov 29
$653
includes taxes & fees
Nov 28 - Nov 29
Stay at this 5-star luxury hotel in Houston. Enjoy free WiFi, a full-service spa, and 4 restaurants. Our guests praise the helpful staff and the room service ...
The Post Oak Hotel at Uptown Houston
Four Seasons Hotel Houston
5 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from MD Anderson Cancer Center
The price is $508 per night from Nov 28 to Nov 29
$508
includes taxes & fees
Nov 28 - Nov 29
Book a stay at this spa hotel in Houston. Enjoy free WiFi, a full-service spa, and 2 restaurants. Popular attractions Toyota Center and Minute Maid Park are ...
Four Seasons Hotel Houston
JW Marriott Houston Downtown
5 out of 5
Fully refundableReserve now, pay when you stay
  • 9 min drive from MD Anderson Cancer Center
The price is $247 per night from Nov 28 to Nov 29
$247
includes taxes & fees
Nov 28 - Nov 29
Stay at this 5-star luxury hotel in Houston. Enjoy a full-service spa, 24-hour room service, and a health club. Our guests praise the helpful staff and the clean ...
JW Marriott Houston Downtown
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The St. Regis Houston
5 out of 5
Fully refundableReserve now, pay when you stay
  • 7 min drive from MD Anderson Cancer Center
The price is $428 per night from Nov 24 to Nov 25
$428
includes taxes & fees
Nov 24 - Nov 25
Stay at this 5-star luxury hotel in Houston. Enjoy a full-service spa, breakfast (surcharge), and 24-hour room service. Popular attractions Houston Zoo and NRG ...
The St. Regis Houston
Hotel Granduca Houston
5 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from MD Anderson Cancer Center
The price is $455 per night from Dec 1 to Dec 2
$455
includes taxes & fees
Dec 1 - Dec 2
Stay at this 5-star luxury aparthotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff and the ...
Hotel Granduca Houston
La Colombe d'Or Hotel
5 out of 5
Fully refundableReserve now, pay when you stay
  • 6 min drive from MD Anderson Cancer Center
The price is $506 per night from Nov 29 to Nov 30
$506
includes taxes & fees
Nov 29 - Nov 30
Stay at this 5-star luxury hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Popular attractions Toyota Center and Houston ...
La Colombe d'Or Hotel
7550 Kirby Dr
5 out of 5
  • 13 min walk from MD Anderson Cancer Center
The price is $195 per night from Dec 12 to Dec 13
$195
includes taxes & fees
Dec 12 - Dec 13
Stay at this 5-star luxury apartment in Houston. Enjoy free WiFi, free parking, and private pools. Popular attractions NRG Stadium and Houston Zoo are located ...
7550 Kirby Dr
TUSCAN VILLA
5 out of 5
  • 5 min drive from MD Anderson Cancer Center
The price is $2,876 per night from Nov 15 to Nov 16
$2,876
includes taxes & fees
Nov 15 - Nov 16
Stay at this 5-star luxury villa in Houston. Enjoy free WiFi, free parking, and in-room massages. Popular attractions Houston Zoo and NRG Stadium are located ...
TUSCAN VILLA
ECLIPZ Modern CEO Corp House
5 out of 5
  • 48 min drive from MD Anderson Cancer Center
The price is $2,125 per night from Nov 15 to Nov 16
$2,125
includes taxes & fees
Nov 15 - Nov 16
Stay at this 5-star luxury villa in Houston. Enjoy free WiFi, valet parking (surcharge), and an airport shuttle (surcharge). Popular attractions Willowbrook ...
ECLIPZ Modern CEO Corp House
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

5-Star Hotel in Houston

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in Houston.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in Houston for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $195.

  • Amenities: Houston skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in Houston—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on Houston your way.