Search for Cheap Deals on
Hotels in Charleston

Choose from 90 Charleston Hotel Deals

Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
2 out of 5
310 S Story St, Charleston, MO
  • 2 hours drive from Shawnee National Forest
The price is $73 per night from Apr 6 to Apr 7
$73
includes taxes & fees
Apr 6 - Apr 7
Stay at this motel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews.
6.6/10 (547 reviews)
"The carpet in the room needs to be vacuumed."

Reviewed on Mar 24, 2025

Super 8 by Wyndham Charleston/Sikeston East MO
Quality Inn Charleston - Sikeston
Quality Inn Charleston - Sikeston
2.5 out of 5
102 Drake St, I-57 Exit 10, Charleston, MO
  • 2 hours drive from Shawnee National Forest
The price is $84 per night from Apr 20 to Apr 21
$84
includes taxes & fees
Apr 20 - Apr 21
Book a stay at this business-friendly hotel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our ...
6.6/10 (374 reviews)
"Staff were very friendly. Room was spacious and well designed."

Reviewed on Mar 17, 2025

Quality Inn Charleston - Sikeston
Eagle Inn Charleston
Eagle Inn Charleston
2 out of 5
2811 East Marshall Street, Charleston, MO
  • 2 hours drive from Shawnee National Forest
The price is $61 per night from May 2 to May 3
$61
includes taxes & fees
May 2 - May 3
Stay at this motel in Charleston. Enjoy free WiFi, free parking, and a health club.
6.6/10 (95 reviews)
"Comfortable bed, easy access to room"

Reviewed on Oct 8, 2024

Eagle Inn Charleston
The Riverview
The Riverview
3.5 out of 5
777 Main St, Cape Girardeau, MO
  • 2 hours drive from Shawnee National Forest
The price is $100 per night from Apr 3 to Apr 4
$100
includes taxes & fees
Apr 3 - Apr 4
Stay at this 3.5-star hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront ...
9.2/10 Wonderful! (207 reviews)
"Beautiful room, view, and great price. We will definitely be coming back! Thank you!"

Reviewed on Apr 1, 2025

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
  • 3 hours drive from Shawnee National Forest
The price is $107 per night from Apr 6 to Apr 7
$107
includes taxes & fees
Apr 6 - Apr 7
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,010 reviews)
"Great place to stay. The free breakfast and early evening drinks & appetizers are the best I've ever had. Both serve hot foods and there are lots of choices. The staff was always friendly and helpful at the eating area and the front desk. The room was quiet even though the hotel was full of teenage ..."

Reviewed on Mar 30, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 out of 5
3253 William Street, Cape Girardeau, MO
  • 3 hours drive from Shawnee National Forest
The price is $116 per night from Apr 13 to Apr 14
$116
includes taxes & fees
Apr 13 - Apr 14
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,003 reviews)
"We enjoyed our stay both times on our vacation to New Orleans."

Reviewed on Mar 29, 2025

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
  • 3 hours drive from Shawnee National Forest
The price is $98 per night from Apr 6 to Apr 7
$98
includes taxes & fees
Apr 6 - Apr 7
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,001 reviews)
Nice find
"Our second visit in route back from New Orleans. Great location right off the highway. The hotel is clean, updated and staff are always friendly. Decent breakfast too."

Reviewed on Apr 1, 2025

Pear Tree Inn Sikeston
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
  • 3 hours drive from Shawnee National Forest
The price is $81 per night from Apr 6 to Apr 7
$81
includes taxes & fees
Apr 6 - Apr 7
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,001 reviews)
"Nice place, would stay here again"

Reviewed on Apr 1, 2025

Pear Tree Inn Cape Girardeau West
Candlewood Suites Cape Girardeau by IHG
Candlewood Suites Cape Girardeau by IHG
2.5 out of 5
485 S Mount Auburn Rd, Cape Girardeau, MO
  • 3 hours drive from Shawnee National Forest
The price is $107 per night from Apr 20 to Apr 21
$107
includes taxes & fees
Apr 20 - Apr 21
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (754 reviews)
Parking.
"The only problem we had was parking. Several people parked in the middle of two spots. A truck and trailer were taking up 6 spots and several spots had trailers and work equipment. They told us we could park in the gravel lot beside the hotel. I would think that is where the trailers and big trucks ..."

Reviewed on Apr 1, 2025

Candlewood Suites Cape Girardeau by IHG
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 out of 5
120 S Interstate Drive, Sikeston, MO
  • 3 hours drive from Shawnee National Forest
The price is $102 per night from Apr 6 to Apr 7
$102
includes taxes & fees
Apr 6 - Apr 7
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,001 reviews)
Nice place to stay , quiet and clean
"The gentleman at the front desk was super nice , friendly and just fun when we checked in , we had a quick overnight stay in town ! Pool was clean nice and warm , the next morning breakfast was nice clean and stocked and the young lady cleaning and keeping it full was very friendly also , plus we ..."

Reviewed on Mar 30, 2025

Best Western Plus Sikeston
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 out of 5
3248 William St, Cape Girardeau, MO
  • 3 hours drive from Shawnee National Forest
The price is $76 per night from Apr 6 to Apr 7
$76
includes taxes & fees
Apr 6 - Apr 7
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, an outdoor pool, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (1,001 reviews)
"It was small room but was okay"

Reviewed on Mar 21, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
  • 3 hours drive from Shawnee National Forest
The price is $114 per night from Apr 6 to Apr 7
$114
includes taxes & fees
Apr 6 - Apr 7
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,000 reviews)
Another great stay
"We have stayed in many drury inn and suites in a variety of cities/towns and this was the best! Friendly people, great suite for a room, great breakfast."

Reviewed on Mar 29, 2025

Drury Inn & Suites Sikeston, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Charleston

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Charleston hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Charleston.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Charleston’s 90 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $61. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Charleston hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Charleston. No matter your reason for visiting Charleston, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Charleston hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Charleston for as low as $61.

How many hotels are there in Charleston?

With over 90 hotels in Charleston, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $61.

How to find cheap car rentals in Charleston?

Finding a cheap car rental deal in Charleston is as easy as scoring cheap hotels in Charleston. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.